Home Shortage of aspartate in mitochondria fuels arthritis
Nature Immunology, Published online: 22 November 2021; doi:10.1038/s41590-021-01069-y
In patients with rheumatoid arthritis, a short supply of aspartate in the mitochondria can force the endoplasmic reticulum of T cells to generate transmembrane TNF, which in turn contributes to synovial inflammation.
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