Nature Immunology, Published online: 09 January 2023; doi:10.1038/s41590-022-01394-w

The formation of an immunological synapse is central to the ability of NK cells to lyse target cells. Here the authors show that Nogo receptor 1 (NgR1) might be a good target for cancer immunotherapy as it destabilizes the NK synapse, resulting in defective killing of tumor cells.