When Genomic DNA Is Found In The Eluant, It Means That Genomic DNA Has Been Sheared During Cell Lysis Process. After MX2 Buffer Is Added, Ensure That Mixing Is Done Very Gently To Prevent Genomic DNA Shearing. If Genomic DNA Is Sheared, Genomic DNA Fragments Will Get Into The Lysate And Copurified With Plasmid.